The Reventón is named for a fighting bull, in line with Lamborghini tradition. The bull, raised by the Don Heriberto Rodríguez family, was best known for killing famed Mexican bullfighter Félix Guzmán in 1943. Reventón means "explosion" or "burst" in Spanish.

The instrument panel in the Lamborghini Reventon comprises three TFT liquid crystal displays (LCDs) with two different display modes. The instruments are housed in a structure milled from a solid aluminium block, protected by a carbon fiber casing. The car's instrumentation includes a "G-Force-Meter" which displays the magnitude and direction of the g-forces acting upon the car. The seats of the Reventón are black leather and brown Alcantara.

The Lamborghini Reventon features an all-new carbon fiber exterior. All Reventóns have the same exterior color, described as "mid opaque grey without the usual shine." Lamborghini has also picked up some of parent company Audi's design language. It is the first Lamborghini to incorporate daylight running lights into the headlamps. Seven light-emitting diodes (LEDs) at each headlamp flank the bi-Xenon main beam and stay lit whenever the car is in movement. Due to the high temperatures in the rear lower part of the car, special heatproof LEDs are used for the indicator and hazard lights, stoplights and rear lights with a triple arrow optical effect.