The Veyron's chief designer was Hartmut Warkuss, and the exterior was designed by Jozef Kabaň of Volkswagen, with much of the engineering work being conducted under the guidance of former Peterbilt engineer and now Bugatti Engineering chief Wolfgang Schreiber.

Bugatti Veyron EB 16.4 was named Car of the Decade (2000–2009) by the BBC television programme Top Gear.

A number of special variants have been produced, including two targa tops. In December 2010, Bugatti began offering prospective buyers the ability to customize exterior and interiors colours by using the Veyron 16.4 Configurator application on the marque's official website.

The Veyron features a 16 cylinder engine, equivalent to two narrow-angle V8 engines mated in a W configuration. Each cylinder has four valves for a total of sixty four, but the narrow staggered V8 configuration allows two overhead camshafts to drive two banks of cylinders so only four camshafts are needed. The engine is fed by four bi-turbochargers and displaces 7,993 cubic centimetres (487.8 cu in), with a square 86 by 86 mm (3.4 by 3.4 in) bore and stroke.

The transmission is a dual-clutch direct-shift gearbox computer-controlled automatic with seven gear ratios, with magnesium paddles behind the steering wheel and a shift time of less than 150 milliseconds, built by Ricardo of England rather than Borg-Warner, who designed the six speed DSG used in the mainstream Volkswagen Group marques. The Veyron can be driven in either semi- or fully automatic mode. A replacement transmission for the Veyron costs just over €120,000. It also has permanent four wheel drive using the Haldex Traction system. It uses special Michelin PAX run flat tires, designed specifically to accommodate the Veyron's top speed, which reportedly cost €25,000 per set.

The tyres can be removed from the rims only in France, a service which reportedly costs €70,000. Curb weight is 2,034.8 kilograms (4,486 lb). This gives the car a power to weight ratio, according to Volkswagen Group's 1,001 metric horsepower (736 kW; 987 bhp) figures, of 446.3 metric horsepower (328 kW; 440 bhp) per ton. The car's wheelbase is 2,710 mm (106.7 in). Overall length is 4,462 mm (175.7 in), width 1,998 mm (78.7 in) and height 1,204 mm (47.4 in).

According to Volkswagen Group and certified by TÜV Süddeutschland, the final production Veyron engine produces 1,001 metric horsepower (736 kW; 987 bhp) of motive power, and generates 1,250 newton metres (922 ft·lbf) of torque.[1][12] The nominal figure has been stated by Bugatti officials to be conservative, with the real total being 1,020 metric horsepower (750 kW; 1,006 bhp) or more.

The Veyron Super Sport features an engine power increase from the standard 1,001 metric horsepower (736 kW; 987 bhp) to 1,200 metric horsepower (883 kW; 1,184 bhp) and torque of 1,500 N·m (1,100 ft·lbf) and a revised aerodynamic package.

The Veyron's brakes use cross drilled, radially vented carbon fibre reinforced silicon carbide (C/SiC) composite discs, manufactured by SGL Carbon, which have a much greater resistance to brake fade when compared with conventional cast iron discs. The lightweight aluminium alloy monobloc brake calipers are made by AP Racing; the fronts have eight titanium pistons and the rear calipers have six pistons. Bugatti claims maximum deceleration of 1.3 g's on road tyres. As an added safety feature, in the event of brake failure, an anti-lock braking system (ABS) has also been installed on the handbrake.